Does Chronic Glycolysis Accelerate Aging? Could This Explain How Dietary Restriction Works?

  title={Does Chronic Glycolysis Accelerate Aging? Could This Explain How Dietary Restriction Works?},
  author={Alan R. Hipkiss},
  journal={Annals of the New York Academy of Sciences},
  • A. Hipkiss
  • Published 1 May 2006
  • Biology
  • Annals of the New York Academy of Sciences
Abstract:  The mechanisms by which dietary restriction (DR) suppresses aging are not understood. Suppression of glycolysis by DR could contribute to controlling senescence. Many glycolytic intermediates can glycate proteins and other macromolecules. Methyglyoxal (MG), formed from dihydroxyacetone‐ and glyceraldehyde‐3‐phosphates, rapidly glycates proteins, damages mitochondria, and induces a prooxidant state to create a senescent‐like condition. Ad libitum‐fed and DR animals differ in… 
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