Does CDP-choline modulate phospholipase activities after transient forebrain ischemia?

@article{Rao2001DoesCM,
  title={Does CDP-choline modulate phospholipase activities after transient forebrain ischemia?},
  author={A. Muralikrishna Rao and James Franklin Hatcher and Robert J Dempsey},
  journal={Brain research},
  year={2001},
  volume={893 1-2},
  pages={268-72}
}
Ten min forebrain ischemia/1-day reperfusion resulted in significant decreases in total phosphatidylcholine (PtdCho), phosphatidylinositol (PtdIns), and cardiolipin in gerbil hippocampus. CDP-choline restored cardiolipin levels, arachidonic acid content of PtdCho, partially but significantly restored total PtdCho, and had no effect on PtdIns. These data suggest that CDP-choline prevented the activation of phospholipase A(2) (rather than inhibiting phospholipase A(2) activity) but did not affect… CONTINUE READING
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