Does BCG vaccination protect against childhood asthma? Final results from the Manchester Community Asthma Study retrospective cohort study and updated systematic review and meta-analysis.

@article{Linehan2014DoesBV,
  title={Does BCG vaccination protect against childhood asthma? Final results from the Manchester Community Asthma Study retrospective cohort study and updated systematic review and meta-analysis.},
  author={Mary F Linehan and Ulugbek B. Nurmatov and Timothy Laszlo Frank and Robert M Niven and David N. Baxter and Aziz Sheikh},
  journal={The Journal of allergy and clinical immunology},
  year={2014},
  volume={133 3},
  pages={688-95.e14}
}
BACKGROUND The Manchester Community Asthma Study (MANCAS) found a protective effect against the risk of wheeze at age 6 to 11 years for children given neonatal BCG vaccination. Our subsequent systematic review and meta-analysis suggested that BCG vaccination did not protect against allergic sensitization but might have exerted a protective effect against nonatopic asthma. OBJECTIVES We sought to assess whether the protective effect of BCG vaccination on wheeze observed in the MANCAS cohort… CONTINUE READING
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