Does Anticipation of Pain Affect Cortical Nociceptive Systems?

@article{Porro2002DoesAO,
  title={Does Anticipation of Pain Affect Cortical Nociceptive Systems?},
  author={Carlo Adolfo Porro and Patrizia Baraldi and Giuseppe Pagnoni and Marco Serafini and Patrizia Facchin and Marta Maieron and Paolo Frigio Nichelli},
  journal={The Journal of Neuroscience},
  year={2002},
  volume={22},
  pages={3206 - 3214}
}
Anticipation of pain is a complex state that may influence the perception of subsequent noxious stimuli. We used functional magnetic resonance imaging (fMRI) to study changes of activity of cortical nociceptive networks in healthy volunteers while they expected the somatosensory stimulation of one foot, which might be painful (subcutaneous injection of ascorbic acid) or not. Subjects had no previous experience of the noxious stimulus. Mean fMRI signal intensity increased over baseline values… 

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