Does Alzheimer's disease begin in the brainstem?

@article{imi2009DoesAD,
  title={Does Alzheimer's disease begin in the brainstem?},
  author={Goran {\vS}imi{\'c} and Gabrijela Stani{\'c} and Mihovil Mladinov and Nata{\vs}a Jovanov-Milo{\vs}evi{\'c} and Ivica Kostovi{\'c} and Patrick R. Hof},
  journal={Neuropathology and applied neurobiology},
  year={2009},
  volume={35 6},
  pages={532-54}
}
Although substantial evidence indicates that the progression of pathological changes of the neuronal cytoskeleton is crucial in determining the severity of dementia in Alzheimer's disease (AD), the exact causes and evolution of these changes, the initial site at which they begin, and the neuronal susceptibility levels for their development are poorly understood. The current clinical criteria for diagnosis of AD are focused mostly on cognitive deficits produced by dysfunction of hippocampal and… CONTINUE READING