Does β2-adrenergic stimulation attenuate fluid extravasation during hypothermic cardiopulmonary bypass? An experimental study in pigs.

@article{Husby2012DoesS,
  title={Does β2-adrenergic stimulation attenuate fluid extravasation during hypothermic cardiopulmonary bypass? An experimental study in pigs.},
  author={Paul J A Husby and Hege Kristin Brekke and Arve Mongstad and Marit Farstad and Oddbj\orn Haugen and Venny Lise Kvalheim},
  journal={Perfusion},
  year={2012},
  volume={27 5},
  pages={426-34}
}
OBJECTIVES Hypothermic cardiopulmonary bypass (CPB) is associated with increased fluid filtration, edema formation and, occasionally, organ dysfunction. Cold-induced reduction in endothelial barrier function may play a role. β(2)-adrenergic activation elevates cellular cyclic adenosine monophosphate (cAMP) which maintains endothelial barrier properties. In this study, we tested whether β-adrenergic stimulation could influence the increase in fluid extravasation observed during hypothermic CPB… CONTINUE READING