Dodging the crisis of folding proteins with knots.

  title={Dodging the crisis of folding proteins with knots.},
  author={Joanna I. Sułkowska and Piotr Sułkowski and Jos{\'e} N. Onuchic},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 9},
Proteins with nontrivial topology, containing knots and slipknots, have the ability to fold to their native states without any additional external forces invoked. A mechanism is suggested for folding of these proteins, such as YibK and YbeA, that involves an intermediate configuration with a slipknot. It elucidates the role of topological barriers and backtracking during the folding event. It also illustrates that native contacts are sufficient to guarantee folding in approximately 1-2% of the… CONTINUE READING