Dodging matrix effects in liquid chromatography tandem mass spectrometric assays--compilation of key learnings and perspectives.

@article{Srinivas2009DodgingME,
  title={Dodging matrix effects in liquid chromatography tandem mass spectrometric assays--compilation of key learnings and perspectives.},
  author={Nuggehally R. Srinivas},
  journal={Biomedical chromatography : BMC},
  year={2009},
  volume={23 5},
  pages={
          451-4
        }
}
Triple quad liquid chromatography mass spectrometric assays (LC/MS/MS) have revolutionized the analysis of drug(s)/metabolite(s) with exceptional speed, sensitivity and selectivity features. From inception to date, several new and innovative features have been regularly proposed by researchers to further enhance the value in the applicability of this analytical tool. However, owing to such compressed run times and scanty sample preparation procedures, LC/MS/MS assays that are not fully… CONTINUE READING

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  • 2015
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 28 REFERENCES

Determination of the lipophilic

G Zhang, Terry AV, MG Bartlett
  • Mass Spectrometry
  • 2008
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of rhein in human plasma: application to a pharmacokinetic study

B Layek, T Santosh Kumar, RK Trivedi, R Mullangi, NR. Srinivas
  • Biomedical Chromatography
  • 2008
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Standard line slopes as a measure of a relative matrix effect in quantitative HPLC-MS bioanalysis.

  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2006
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses.

  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2007
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL