Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis.

@article{Kennaway2005DodecamericSO,
  title={Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis.},
  author={Christopher K. Kennaway and Justin L P Benesch and Ulrich Gohlke and Luchun Wang and Carol V Robinson and Elena V Orlova and Helen R Saibil and Nicholas H Keep},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 39},
  pages={33419-25}
}
Small heat shock proteins are a ubiquitous and diverse family of stress proteins that have in common an alpha-crystallin domain. Mycobacterium tuberculosis has two small heat shock proteins, Acr1 (alpha-crystallin-related protein 1, or Hsp16.3/16-kDa antigen) and Acr2 (HrpA), both of which are highly expressed under different stress conditions. Small heat shock proteins form large oligomeric assemblies and are commonly polydisperse. Nanoelectrospray mass spectrometry showed that Acr2 formed a… CONTINUE READING
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