Documentation of Acute Rise in Ventricular Capture Thresholds Associated with Flecainide Acetate

  title={Documentation of Acute Rise in Ventricular Capture Thresholds Associated with Flecainide Acetate},
  author={Helio Fornieles-P{\'e}rez and Matilde Montoya-Garc{\'i}a and Paul A. Levine and Oscar Javier S{\'a}nchez Sanz},
  journal={Pacing and Clinical Electrophysiology},
FORNIELES‐PÉREZ, H., et al.: Documentation of Acute Rise in Ventricular Capture Thresholds Associated with Flecainide Acetate. Treatment of paroxysmal atrial fibrillation with flecainide acetate resulted in a 4‐fold increase in ventricular capture thresholds. The detailed time course of the threshold increase and decrease was documented using the AutoCapture algorithm and graphic summary. 

A Case of Acute Ventricular Capture Threshold Rise Associated with Flecainide Acetate

The case of a 72-year-old male, with a previously implanted VVI pacemaker due to sick sinus syndrome, who was treated with flecainide acetate for paroxysmal atrial arrhythmia control, an abrupt rise in the ventricular capture threshold with ventricular pacing failure was noted.

Increased capture threshold in permanent His‐bundle pacing associated with flecainide

This is the first documented case of a rise in selective His‐bundle capture threshold associated with flecainide acetate and further studies are needed to characterize this association which could result in higher capture thresholds, decreased battery longevity, and mimic His‐ bundle lead failure.

A Case of Syncope Resulting From Pacemaker Capture Loss Due to Flecainide Treatment and Hepatotoxicity

A case presenting with syncope resulting from pacemaker capture loss due to flecainide treatment and hepatotoxcitiy is reported.

Causes of Failure to Capture in Pacemakers and Implantable Cardioverter-defibrillators

A knowledge of these factors is essential for health care providers, given the morbidity and mortality that can potentially be associated with device-related issues, especially in patients who are dependent on the included pacing function.

Use of the AutoCapture Pacing System with Implantable Defibrillator Leads

Automatic threshold tracking using the AC is compatible with ICD leads and offers the potential for increasing ICD generator longevity and improving patient safety in response to late unexpected threshold increases.

Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/− murine hearts modelling the Brugada syndrome

Proarrhythmic effects of flecainide in WT and Scn5a+/− murine hearts that recapitulate its clinical effects are demonstrated and attribute the arrhythmogenic phenomena observed here to re‐entrant substrates resulting from delayed epicardial activation despite an absence of transmural heterogeneities of repolarization.

Non-investigational antiarrhythmic drugs: long-term use and limitations

Antiarrhythmic drugs are still justified in patients who prefer this treatment or who cannot be cured by catheter ablation owing to technical problems or lack of treatment capacity, with focus on efficacy, side effects, drug interactions and pro arrhythmmic problems in adult patients.

Hip to pieces, torpid heart?

A 87-year old patient received a dual chamber pacemaker because of third degree atrioventricular block after surgical aortic valve replacement and was admitted to the hospital after an accidental fall with hip fracture for which hip surgery was performed.



Acute Loss of Capture Due to Flecainide Acetate

Administration of flecainide acetate in a 75‐year‐old woman with an implanted AAIR pacemaker because of sick sinus syndrome caused an abrupt rise of pacing threshold and failure of pacing.

Pacing Failure Due to Flecainide Acetate

The need for caution when using this drug in elderly pacemaker patients is stressed, as an abrupt and potentially lethal rise in threshold causing failure of a properly functioning, newly implanted pacing system has not to the authors' knowledge been described.

Effect of the Antiarrhythmic Agent Flecainide Acetate on Acute and Chronic Pacing Thresholds

Fleckcainide significantly increased both acute and chronic thresholds and the most marked rise (> 200%) occurred during chronic oral therapy.

Automatic Adjustment of Pacemaker Stimulation Output Correlated with Continuously Monitored Capture Thresholds: A Multicenter Study

Tbis study proved that the Autocapture safely and reliably regulates the pacemaker's output according to the prevailing threshold thus providing maximum patient safety and prolonging service life.

Cardiac Arrhythmias and Device Therapy: Results and Perspectives for the New Century.

This book presents the landmark clinical trials that have been conducted to evaluate various antiarrhythmic therapies, in chronological order, covering a total of 17 trials since the early 1980s.

Antiarrhythmic drugs.

Clinical experience with dual chamber ventricular Au - toCapture