Docosahexaenoic acid withstands the Aβ(25-35)-induced neurotoxicity in SH-SY5Y cells.

@article{Hashimoto2011DocosahexaenoicAW,
  title={Docosahexaenoic acid withstands the Aβ(25-35)-induced neurotoxicity in SH-SY5Y cells.},
  author={Michio Hashimoto and Masanori Katakura and Shahdat Hossain and Azizur Rahman and Toshio Shimada and Osamu Shido},
  journal={The Journal of nutritional biochemistry},
  year={2011},
  volume={22 1},
  pages={22-9}
}
BACKGROUND Docosahexaenoic acid (DHA, C22:6, n-3) ameliorates the memory-related learning deficits of Alzheimer's disease (AD), which is characterized by fibrillar amyloid deposits in the affected brains. Here, we have investigated whether DHA-induced inhibition of Amyloid β-peptide(25-35) (Aβ(25-35)) fibrillation limits or deteriorates the toxicity of the human neuroblastoma cells (SH-SY5Y). EXPERIMENTAL METHODS In vitro fibrillation of Aβ(25-35) was performed in the absence or presence of… CONTINUE READING
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