Docosahexaenoic acid selectively inhibits plasma membrane targeting of lipidated proteins.

@article{Seo2006DocosahexaenoicAS,
  title={Docosahexaenoic acid selectively inhibits plasma membrane targeting of lipidated proteins.},
  author={Jeongmin Seo and Rola Barhoumi and Arthur E. Johnson and Joanne R. Lupton and Robert S. Chapkin},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2006},
  volume={20 6},
  pages={770-2}
}
Membrane localization of lipidated cytosolic signaling proteins is mediated by interactions between specific lipid anchors and membranes, but little is known about the regulatory role of membrane composition in lipidated protein membrane targeting. Here, using green fluorescent protein (GFP) chimeras and quantitative fluorescence microscopy in living mouse colonocytes, we show that docosahexaenoic acid (DHA), a dietary polyunsaturated fatty acid (PUFA) with membrane lipid-modifying properties… CONTINUE READING

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