Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix-loop-helix transcription factors and cell cycle in neural stem cells.

@article{Katakura2009DocosahexaenoicAP,
  title={Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix-loop-helix transcription factors and cell cycle in neural stem cells.},
  author={Masanori Katakura and Makoto Hashimoto and Hossain Md Shahdat and Shuji Gamoh and Toshiyuki Okui and Kyoichi Matsuzaki and Osamu Shido},
  journal={Neuroscience},
  year={2009},
  volume={160 3},
  pages={651-60}
}
Recent studies have suggested that docosahexaenoic acid (DHA) enhances neuronal differentiation of neural stem cells (NSCs) isolated from rat embryonic day 14.5. However the underlying mechanism remains largely unknown. One hypothesis supported by DHA controls the expression level of basic helix-loop-helix (bHLH) transcription factors, such as hairy and enhancer of split 1 (Hes1), Mash1, neurogenin1, and NeuroD; another is that previous studies in retinal progenitor cells DHA affects the cell… CONTINUE READING
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