Docosahexaenoic acid promotes neurogenesis in vitro and in vivo.

  title={Docosahexaenoic acid promotes neurogenesis in vitro and in vivo.},
  author={Eisuke Kawakita and Makoto Hashimoto and Osamu Shido},
  volume={139 3},
Docosahexaenoic acid (22:6n-3), one of the main structural lipids in the mammalian brain, plays crucial roles in the development and function of brain neurons. We examined the effect of docosahexaenoic acid on neuronal differentiation of neural stem cells in vitro and in vivo. Neural stem cells obtained from 15.5-day-old rat embryos were propagated as neurospheres and cultured under differential conditions with or without docosahexaenoic acid for 4 and 7 days. Docosahexaenoic acid significantly… CONTINUE READING