Docosahexaenoic acid lowers phosphatidate level in human activated lymphocytes despite phospholipase D activation.

@article{Bechoua1998DocosahexaenoicAL,
  title={Docosahexaenoic acid lowers phosphatidate level in human activated lymphocytes despite phospholipase D activation.},
  author={Shaliha Bechoua and Madeleine Dubois and Georges M. N{\'e}moz and Michel Lagarde and Annie France Prigent},
  journal={Journal of lipid research},
  year={1998},
  volume={39 4},
  pages={873-83}
}
N-3 polyunsaturated fatty acids from marine oil have been shown to decrease T cell-mediated immune function both in animals and humans, and to inhibit the mitogen-induced lymphoproliferative response when added to lymphocyte culture medium. As phosphatidic acid (PA) is a key mediator of the mitogenic process, the present study aims to investigate whether docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids, the main n-3 fatty acids from fish oil, are able to alter the mitogen-induced… CONTINUE READING