Docosahexaenoic acid is a beneficial replacement treatment for spinocerebellar ataxia 38

@inproceedings{Manes2017DocosahexaenoicAI,
  title={Docosahexaenoic acid is a beneficial replacement treatment for spinocerebellar ataxia 38},
  author={Marta Manes and Antonella Alberici and Eleonora di Gregorio and Loredana Boccone and Enrico Premi and Nico Mitro and Maria Pia Pasolini and Claudia Pani and Barbara Paghera and Daniela Perani and Laura Orsi and Chiara Costanzi and Marta Ferrero and Adele Zoppo and Filippo Tempia and Donatella Caruso and Mario Grassi and Alessandro Padovani and Alfredo Brusco and Barbara Borroni},
  booktitle={Annals of neurology},
  year={2017}
}
OBJECTIVE Spinocerebellar ataxia 38 (SCA38) is caused by mutations in the ELOVL5 gene, which encodes an elongase involved in the synthesis of polyunsaturated fatty acids, including docosahexaenoic acid (DHA). As a consequence, DHA is significantly reduced in the serum of SCA38 subjects. In the present study, we evaluated the safety of DHA supplementation, its efficacy for clinical symptoms, and changes of brain functional imaging in SCA38 patients. METHODS We enrolled 10 SCA38 patients, and… CONTINUE READING
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