Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice.
@article{Horie1998DocosahexaenoicAE, title={Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice.}, author={T. Horie and M. Nakamaru and Y. Masubuchi}, journal={Life sciences}, year={1998}, volume={62 15}, pages={ 1333-8 } }
Oral administration of methotrexate (MTX) to mice causes the damage of small intestine. The permeability of poorly absorbable compound fluorescein isothiocyanate (FITC)-labeled dextran (average molecular weight, 4,400) through the small intestine was studied in vitro using everted segments of the small intestine. The permeability of FITC-dextran increased remarkably in the MTX-treated mice and oral administration of docosahexaenoic acid ethyl ester (DHA) protected the small intestine from the… CONTINUE READING
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