Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice.

@article{Horie1998DocosahexaenoicAE,
  title={Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice.},
  author={T. Horie and M. Nakamaru and Y. Masubuchi},
  journal={Life sciences},
  year={1998},
  volume={62 15},
  pages={
          1333-8
        }
}
  • T. Horie, M. Nakamaru, Y. Masubuchi
  • Published 1998
  • Biology, Medicine
  • Life sciences
    • Oral administration of methotrexate (MTX) to mice causes the damage of small intestine. The permeability of poorly absorbable compound fluorescein isothiocyanate (FITC)-labeled dextran (average molecular weight, 4,400) through the small intestine was studied in vitro using everted segments of the small intestine. The permeability of FITC-dextran increased remarkably in the MTX-treated mice and oral administration of docosahexaenoic acid ethyl ester (DHA) protected the small intestine from the… CONTINUE READING
    View on PubMed
    doi.org
    32 Citations
    Background Citations
    14
    Results Citations
    1
    32 Citations
    Citation Type

    Citation Type

    Protective effect of a synthetic analog of prostaglandin E(1) on the small intestinal damage induced by the administration of methotrexate to rats.
    • 14
    Alleviation by garlic of antitumor drug-induced damage to the intestine.
    • 23
    • PDF
    Oxidative stress and enhanced paracellular permeability in the small intestine of methotrexate-treated rats
    • 46
    Intervention of alpha-lipoic acid ameliorates methotrexate-induced oxidative stress and genotoxicity: A study in rat intestine.
    • 46
    Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats
    • 130
    Modulation of methotrexate-induced intestinal mucosal injury by dietary factors
    Changes in intestinal absorption of 5-fluorouracil-treated rats.
    • 17
    Aged garlic extract protects against methotrexate-induced apoptotic cell injury of IEC-6 cells.
    • 21
    • PDF
    In vivo effects of highly purified docosahexaenoic acid on rectal insulin absorption.
    • 42
    Protective effects of dietary enrichment with docosahexaenoic acid plus protein in 5-fluorouracil-induced intestinal injury in the rat
    • 26

    References

    SHOWING 1-10 OF 19 REFERENCES
    Evaluation of damaged small intestine of mouse following methotrexate administration
    • 31
    Amelioration of methotrexate-induced malabsorption by vitamin A
    • 21
    Protective effect of vitamin A against the methotrexate-induced damage to small intestine: a study on the crypt cells.
    • 25
    The effect of oral methotrexate on the rat intestine.
    • 53
    Effects of mitomycin C, 5-fluorouracil and cyclophosphamide on drug absorption, enzyme activities and mucosal lipid composition of intestine.
    • 14
    Response of the rat small-intestine epithelium to methotrexate.
    • 122
    • PDF
    Receptor-mediated absorption of high molecular weight dextrans from intestinal tract
    • 14
    Effects of protease inhibitors on the absorption of phenol red and fluorescein isothiocyanate dextrans from the rat intestine.
    • 33
    Vitamin A, a useful biochemical modulator capable of preventing intestinal damage during methotrexate treatment.
    • 21
    Docosahexaenoic acid is a potent inhibitor of rat uterine stromal cell proliferation.
    • 22