Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice.

@article{Horie1998DocosahexaenoicAE,
  title={Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice.},
  author={Toshiharu Horie and Michihiko Nakamaru and Yasuhiro Masubuchi},
  journal={Life sciences},
  year={1998},
  volume={62 15},
  pages={
          1333-8
        }
}
Oral administration of methotrexate (MTX) to mice causes the damage of small intestine. The permeability of poorly absorbable compound fluorescein isothiocyanate (FITC)-labeled dextran (average molecular weight, 4,400) through the small intestine was studied in vitro using everted segments of the small intestine. The permeability of FITC-dextran increased remarkably in the MTX-treated mice and oral administration of docosahexaenoic acid ethyl ester (DHA) protected the small intestine from the… Expand
View on PubMed
doi.org
33 Citations
Background Citations
13
Results Citations
1

33 Citations

Citation Type

Citation Type

Protective effect of a synthetic analog of prostaglandin E(1) on the small intestinal damage induced by the administration of methotrexate to rats.
TLDR
Results show that OP-1206 alleviates the methotrexate-induced damage to the small intestine of rats, using in vitro everted intestine and in situ intestinal loop techniques. Expand
Alleviation by garlic of antitumor drug-induced damage to the intestine.
TLDR
Results suggest that AGE may protect the small intestine of rats from antitumour drug-induced damage, and may even protect against damage from aged garlic extract. Expand
Oxidative stress and enhanced paracellular permeability in the small intestine of methotrexate-treated rats
TLDR
NAC protected the small intestine of rats from MTX-induced change in paracellular permeability, suggesting that ROS played an important role in the enhanced parace cellular permeability. Expand
Intervention of alpha-lipoic acid ameliorates methotrexate-induced oxidative stress and genotoxicity: A study in rat intestine.
TLDR
It is reported that LA pretreatment ameliorates MTX-induced intestinal toxicity in rat as evident from the protection against oxidative stress, decrease in DNA damage and protection of cellular morphology as well as improvement in the stool consistency and animal survival rate. Expand
Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats
TLDR
It is suggested that oxidative stress plays an important role in the MTX-induced small intestinal damage, especially neutrophil infiltration, and the modulation of oxidative stress would be useful in reducing intestinal damage in MTX treatment. Expand
Modulation of methotrexate-induced intestinal mucosal injury by dietary factors
TLDR
HFHSD may modify MTX-induced toxicity in intestinal epithelia on account of an altered MTX distribution as a result of change in the intestinal environment, and microbiome and metabolome analyses on feces suggest a similarity of the intestinal environments of mice fed NC and HFHSD-M. Expand
Changes in intestinal absorption of 5-fluorouracil-treated rats.
TLDR
The administration of 5-fluorouracil to rats caused body weight loss and epithelial barrier dysfunction of the small intestine in rats as shown by the increased permeation of the high molecular weight compound, fluorescein isothiocyanate-labelled dextran. Expand
Aged garlic extract protects against methotrexate-induced apoptotic cell injury of IEC-6 cells.
TLDR
Results indicated that AGE protects IEC-6 cells from the MTX-induced damage, which may be useful in cancer chemotherapy with MTX because it reduces MTx-induced intestinal damage. Expand
In vivo effects of highly purified docosahexaenoic acid on rectal insulin absorption.
TLDR
It is demonstrated that DHA has a strong insulin permeability enhancement effect and little toxicity, and is an attractive candidate as an absorption enhancer for intestinal delivery of insulin. Expand
Protective effects of dietary enrichment with docosahexaenoic acid plus protein in 5-fluorouracil-induced intestinal injury in the rat
TLDR
Enriching the diet with DHA protects against intestinal lesions produced by the anti-tumoural drug 5-FU but requires the joint administration of supplementary protein and growth hormone to reduce the noxious effects of 5-fu. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 19 REFERENCES
Evaluation of damaged small intestine of mouse following methotrexate administration
TLDR
Evaluating the damage to the small intestine of mice caused by MTX administration revealed that MTX treatment disorders the paracellular barrier function of the small intestinal epithelium, resulting in increased permeation of nonabsorbable markers via the parACEllular pathway of theSmall intestinal mucosa. Expand
Amelioration of methotrexate-induced malabsorption by vitamin A
TLDR
It is found that the coadministration of vitamin A (VA) with MTX protected the small intestine from MTX-induced damage, and it seems likely that VA ameliorates MTx-induced malabsorption. Expand
Protective effect of vitamin A against the methotrexate-induced damage to small intestine: a study on the crypt cells.
TLDR
Although the oral administration of MTX to rats inhibited DNA synthesis in crypt cells, VA coadministration protected the salvage pathway of pyrimidine synthesis and the de novo purine synthesis in Crypt cells. Expand
The effect of oral methotrexate on the rat intestine.
TLDR
The ingestion of this drug has provided an excellent model by which the functional activity of the intestinal mucosa can be correlated with the histological findings, and it is suggested that clinical studies on intestinal biopsy samples should include functional tests as well as histological examinations whenever possible. Expand
Effects of mitomycin C, 5-fluorouracil and cyclophosphamide on drug absorption, enzyme activities and mucosal lipid composition of intestine.
TLDR
Toxicity to intestinal mucosa was shown to derive from an effect on dividing cells in the crypts because MMC and 5-FU preferentially decreased thymidine kinase activity, and increased mucosal membrane permeability was confirmed at the membrane level. Expand
Response of the rat small-intestine epithelium to methotrexate.
TLDR
In the small intestine under conditions of altered epithelial renewal, some components of enterocyte function may be affected more than others and the nature of the original intestinal injury is a significant determinant of the pattern of enterocytes response. Expand
Receptor-mediated absorption of high molecular weight dextrans from intestinal tract
TLDR
The in vitro permeation study showed that the permeation of [ 3 H]dextran was comparably inhibited by the addition of isomaltose or phlorizin, and also by lowering the temperature from 37°C to 4°C. Expand
Effects of protease inhibitors on the absorption of phenol red and fluorescein isothiocyanate dextrans from the rat intestine.
TLDR
It is suggested that bacitracin has not only a protease-inhibitory but also an absorption-enhancing capability, and may be a good model adjuvant for improving the intestinal absorption of poorly absorbable drugs. Expand
Vitamin A, a useful biochemical modulator capable of preventing intestinal damage during methotrexate treatment.
TLDR
Biochemical modulation used to prevent methotrexate-induced malabsorption by vitamin A coadministration will be of great use in metotrexate cancer chemotherapy. Expand
Docosahexaenoic acid is a potent inhibitor of rat uterine stromal cell proliferation.
TLDR
The inhibitory effect of DHA was independent of the eicosanoid biosynthesis and lipid peroxidation, since it was not reversed by the addition of the antioxidant BHT and no significant production of oxidized species from DHA occurred in the authors' culture conditions. Expand
...
1
2
...