Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice.

@article{Horie1998DocosahexaenoicAE,
  title={Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice.},
  author={Toshiharu Horie and Michihiko Nakamaru and Yasuhiro Masubuchi},
  journal={Life sciences},
  year={1998},
  volume={62 15},
  pages={
          1333-8
        }
}
Oral administration of methotrexate (MTX) to mice causes the damage of small intestine. The permeability of poorly absorbable compound fluorescein isothiocyanate (FITC)-labeled dextran (average molecular weight, 4,400) through the small intestine was studied in vitro using everted segments of the small intestine. The permeability of FITC-dextran increased remarkably in the MTX-treated mice and oral administration of docosahexaenoic acid ethyl ester (DHA) protected the small intestine from the… Expand
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