Docosahexaenoic acid ethyl ester and its ultraviolet degradation products showed DNA-breaking activity in vitro and cytotoxic effects on the HSC-4 cell line.

@article{Liu1995DocosahexaenoicAE,
  title={Docosahexaenoic acid ethyl ester and its ultraviolet degradation products showed DNA-breaking activity in vitro and cytotoxic effects on the HSC-4 cell line.},
  author={Wen Bin Liu and Hiroyuki Nishio and Takaya Mio and Kaoru Sumino},
  journal={The Kobe journal of medical sciences},
  year={1995},
  volume={41 6},
  pages={235-45}
}
The DNA-breaking activity and cytotoxicity of docosahexaenoic acid ethyl ester (DHAE) and its degradation products (dDHAE) induced by ultraviolet (UV) irradiation, were demonstrated in this study. The major component of dDHAE was identified as 4-hydroxyvaleric acid ethyl ester. DHAE and dHAE solutions at a concentration of 100 mg/ml induced single-strand… CONTINUE READING