Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans.

@article{Mori1999DocosahexaenoicAB,
  title={Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans.},
  author={T. A. Mori and Danny Q. Bao and Valerie Burke and Ian B Puddey and Lawrence J Beilin},
  journal={Hypertension},
  year={1999},
  volume={34 2},
  pages={
          253-60
        }
}
Animal studies suggest that the 2 major omega3 fatty acids found in fish, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may have differential effects on blood pressure (BP) and heart rate (HR). The aim of this study was to determine whether there were significant differences in the effects of purified EPA or DHA on ambulatory BP and HR in humans. In a double-blind, placebo-controlled trial of parallel design, 59 overweight, mildly hyperlipidemic men were randomized to 4 g/d of… 
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Differential Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Vascular Reactivity of the Forearm Microcirculation in Hyperlipidemic, Overweight Men
TLDR
Improvements in endothelium-independent mechanisms appear to be predominant and may contribute to the selective blood pressure–lowering effect observed with DHA compared with EPA in humans.
Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension.
TLDR
EPA and DHA had similar benefits on lipids but adverse effects on short-term glycemic control in hypertensive diabetic patients and the overall implications for cardiovascular disease require long-term evaluation.
Docosahexaenoic acid, but not eicosapentaenoic acid, lowers ambulatory blood pressure and shortens interval QT in spontaneously hypertensive rats in vivo.
Low-dose docosahexaenoic acid lowers diastolic blood pressure in middle-aged men and women.
TLDR
It is indicated that a moderate increase in the daily intake of DHA lowers diastolic BP but does not influence indices of endothelial function or arterial stiffness in the short term.
Effect of docosahexaenoic acid monoacylglyceride on systemic hypertension and cardiovascular dysfunction.
TLDR
Findings revealed that per os administration of MAG-DHA prevents HFHC-diet induced hypertension and LVH in rats.
Distinguishing Health Benefits of Eicosapentaenoic and Docosahexaenoic Acids
TLDR
To review studies that have identified divergent responses to EPA and DHA, potential contributing factors such as differential membrane incorporation, modulation of gene expression, activation of signaling pathways and metabolite formation are reviewed.
Docosahexaenoic acid reduces resting blood pressure but increases muscle sympathetic outflow compared with eicosapentaenoic acid in healthy men and women.
TLDR
DHA and OO evoked similar responses in resting BP; however, DHA, but not OO, increased peripheral vasoconstrictor outflow and may have implications for fatty acid supplementation in clinical populations characterized by chronic high BP and sympathetic overactivation.
The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans.
TLDR
EPA and DHA increase SAC and tend to reduce pulse pressure and total vascular resistance, effects that may reduce the risk of adverse cardiovascular events.
Microalgal docosahexaenoic acid decreases plasma triacylglycerol in normolipidaemic vegetarians: a randomised trial.
Triacylglycerol (TG) lowering effects of n-3 long-chain PUFA (n-3 LCPUFA) have been repeatedly demonstrated, but studies investigating the individual effects of EPA or DHA on plasma TG and…
Consumption of Fish Oil Providing Amounts of Eicosapentaenoic Acid and Docosahexaenoic Acid That Can Be Obtained from the Diet Reduces Blood Pressure in Adults with Systolic Hypertension: A Retrospective Analysis.
TLDR
Findings indicate that in adults with isolated systolic hypertension, daily doses of EPA+DHA as low as 0.7 g show clinically meaningful BP reductions, which, at a population level, could be associated with lower cardiovascular disease risk.
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References

SHOWING 1-10 OF 45 REFERENCES
Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans.
TLDR
It is concluded that dietary DHA and EPA influence heart rate and that the fatty acid composition of plasma phospholipids may affect cardiac mechanics in humans.
Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. A population-based intervention trial from the Tromsø study.
TLDR
It is concluded that eicosapentaenoic and docosahexaenoic acids reduce blood pressure in essential hypertension, depending on increases in plasma phospholipid n-3 fatty acids.
Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids.
TLDR
It is concluded that both DHA and EPA decrease serum triacylglycerols, but have differential effects on lipoprotein and fatty acid metabolism in humans.
The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans
TLDR
The results from this study on blood clotting parameters and in vitro platelet aggregation suggest that adding 6 g/d of dietary DHA for 90 d to a typical Western diet containing less than 50 mg/D of DHA produces no observable physiological changes in blood coagulation, platelet function, or thrombotic tendencies in healthy, adult males.
The hypotensive effect of docosahexaenoic acid is associated with the enhanced release of ATP from the caudal artery of aged rats.
TLDR
Results suggest that in aged rats, supplementation with DHA alters the membrane fatty acid composition as well as the amount of ATP released from vascular endothelial cells and decreases plasma noradrenaline, and that these factors may ameliorate the rise in blood pressure normally associated with advancing age.
The cardiovascular protective role of docosahexaenoic acid.
The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension.
TLDR
The data indicate that high doses of fish oil can reduce blood pressure in men with essential hypertension, however, the clinical usefulness and safety ofFish oil in the treatment of hypertension will require further study.
Effects of highly purified eicosapentaenoic acid on plasma beta thromboglobulin level and vascular reactivity to angiotensin II.
TLDR
From the data presented it can be said that EPA-E causes a mild depression of vascular contractility and of platelet aggregability in vivo and exerts a beneficial influence on several cardiovascular factors.
Differential effects of dietary fish oil on myocardial prostaglandin I2 and thromboxane A2 production.
TLDR
The present data on myocardial eicosanoids correlate well with the beneficial qualities of (n-3) and ( n-6) dietary PUFA on cardiac function that the authors have reported previously and are offered as likely mechanisms for the greater inhibition of TxA2 compared with PGI2 production observed in the present and previous studies.
Platelet Function, Thromboxane Formation and Blood Pressure Control During Supplementation of the Western Diet with Cod Liver Oil
TLDR
Whatever the mechanism, this moderate supplement of w-3 polyunsaturated fatty acids markedly changed membrane phospholipids, which was associated with a shift toward less reactive platelets and a blunted circulatory response to pressure hormones.
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