Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties.

@article{Balvers2010DocosahexaenoicAA,
  title={Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties.},
  author={M G J Balvers and Kitty Catharina Maria Verhoeckx and Pierluigi Plastina and Heleen M. Wortelboer and J. Beurskens Meijerink and Renger F. Witkamp},
  journal={Biochimica et biophysica acta},
  year={2010},
  volume={1801 10},
  pages={
          1107-14
        }
}
n-3 PUFAs have beneficial health effects which are believed to be partly related to their anti-inflammatory properties, however the exact mechanisms behind this are unknown. One possible explanation could be via their conversion to N-acyl ethanolamines (NAEs), which are known to possess anti-inflammatory properties. Using fatty acid precursors we showed that 3T3-L1 adipocytes are indeed able to convert docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) to their NAE derivatives… CONTINUE READING
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