Docosahexaenoic acid ameliorates palmitate-induced lipid accumulation and inflammation through repressing NLRC4 inflammasome activation in HepG2 cells

@inproceedings{Luo2012DocosahexaenoicAA,
  title={Docosahexaenoic acid ameliorates palmitate-induced lipid accumulation and inflammation through repressing NLRC4 inflammasome activation in HepG2 cells},
  author={Xiaoqin Luo and Yan Yang and Tianran Shen and Xilan Tang and Yunjun Xiao and Tangbin Zou and Min Xia and Wenhua Ling},
  booktitle={Nutrition & metabolism},
  year={2012}
}
BACKGROUND N-3 polyunsaturated fatty acids, such as docosahexaenoic acid (DHA; 22:6n-3), has clinical significance in the prevention and reversal of nonalcoholic steatohepatitis (NASH). However, the precious mechanism underlying remains unclear. The inflammasome, a multiprotein complex formed by NOD-like receptor (NLR) family members, has been recently shown to be activated in NASH and promote the cleavage of the pro-inflammatory cytokines to their maturation forms. METHODS HepG2 cells were… CONTINUE READING

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