Docosahexaenoic acid (DHA) has neuroprotective effects against oxidative stress in retinal ganglion cells

@article{Shimazawa2009DocosahexaenoicA,
  title={Docosahexaenoic acid (DHA) has neuroprotective effects against oxidative stress in retinal ganglion cells},
  author={Masamitsu Shimazawa and Yoshimi Nakajima and Yukihiko Mashima and Hideaki Hara},
  journal={Brain Research},
  year={2009},
  volume={1251},
  pages={269-275}
}
We examined the radical-scavenging activity of docosahexaenoic acid (DHA) and its effects on the neuronal cell death induced by oxidative or hypoxic stress in cultured retinal ganglion cells (RGC-5, a rat ganglion cell-line transformed using E1A virus). The radical-scavenging activity [hydrogen peroxide (H(2)O(2)), superoxide anion (O(2)*(-)), and hydroxyl radical (*OH)] of DHA in RGC-5 cells was measured using the ROS-sensitive probes CM-H(2)DCFDA and APF. DHA concentration-dependently… CONTINUE READING

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