Docosahexaenoic acid, a constituent of fetal and neonatal serum, inhibits nitric oxide production by murine macrophages stimulated by IFN gamma plus LPS, or by IFN gamma plus Listeria monocytogenes.

@article{Lu1998DocosahexaenoicAA,
  title={Docosahexaenoic acid, a constituent of fetal and neonatal serum, inhibits nitric oxide production by murine macrophages stimulated by IFN gamma plus LPS, or by IFN gamma plus Listeria monocytogenes.},
  author={Christopher Y. H. Lu and Jeffery G. Penfield and Tarik A Khair-El-Din and Stanley C. Sicher and Mariusz L. Kielar and Miguel A. V{\'a}zquez and Luanqing Che},
  journal={Journal of reproductive immunology},
  year={1998},
  volume={38 1},
  pages={31-53}
}
Murine macrophage activation is deficient in the fetus and the neonate, and in areas of the placenta perfused by the fetal circulation. Fetal and neonatal serum concentrations of docosahexaenoic acid (DHA) are 150 microM, or approximately 50-fold higher than in the adult. We previously showed that DHA inhibits activation of the gene for inducible nitric oxide synthase (iNOS) in murine macrophages stimulated in vitro with interferon gamma (IFN gamma) plus lipopolysaccharide (LPS). We have now… CONTINUE READING

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