Docosahexaenoic Acid Induces Cell Death through Downregulation of Hedgehog Signaling via Surt 6 Activation in Human EGFR Mutant Non-Small Cell Lung Cancer

Abstract

Omega-3 polyunsaturated fatty acids (ω3-PUFAs), including docosahexaenoic acid (DHA), have been shown to exert anticancer effects by inducing apoptotic cell death. However, the mechanism for DHA-induced cell death in lung cancer is not fully understood. Here, we show that DHA induces apoptosis in two human EGFR mutant non-small cell lung cancer (NSCLC) cell… (More)

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