Docking of Fatty Acids into the WIF Domain of the Human Wnt Inhibitory Factor-1
@article{Malinauskas2007DockingOF, title={Docking of Fatty Acids into the WIF Domain of the Human Wnt Inhibitory Factor-1}, author={Tomas Malinauskas}, journal={Lipids}, year={2007}, volume={43}, pages={227-230} }
Palmitoylated Wnt proteins comprise a conserved family of secreted signaling molecules associated with variety of human cancers. WIF domain of the human WIF (Wnt inhibitory factor)-1 is sufficient for Wnt binding and signaling inhibition. Detailed interactions between Wnt and WIF-1 are not known. Computational docking was employed to identify a possible fatty acid binding site in the WIF domain. A putative binding site was identified inside the domain. WIF domain exhibited the highest affinity… CONTINUE READING
12 Citations
Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1
- Biology, Medicine
- Nature Structural &Molecular Biology
- 2011
- 113
- PDF
Prediction of Structure of Human WNT-CRD (FZD) Complex for Computational Drug Repurposing
- Biology, Medicine
- PloS one
- 2013
- 9
- PDF
The Role of Glypicans in Wnt Inhibitory Factor-1 Activity and the Structural Basis of Wif1's Effects on Wnt and Hedgehog Signaling
- Biology, Medicine
- PLoS genetics
- 2012
- 35
- PDF
Structural Insights into the Inhibition of Wnt Signaling by Cancer Antigen 5T4/Wnt-Activated Inhibitory Factor 1
- Biology, Medicine
- Structure
- 2014
- 34
WIF1 can effectively co-regulate pro-apoptotic activity through the combination with DKK1.
- Biology, Medicine
- Cellular signalling
- 2014
- 11
Secretion and extracellular space travel of Wnt proteins.
- Biology, Medicine
- Current opinion in genetics & development
- 2013
- 46
Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis
- Biology, Medicine
- Journal of Cell Science
- 2009
- 94
- PDF
Extracellular modulators of Wnt signalling.
- Biology, Medicine
- Current opinion in structural biology
- 2014
- 74
The Drosophila WIF1 homolog Shifted maintains glypican-independent Hedgehog signaling and interacts with the Hedgehog co-receptors Ihog and Boi
- Biology, Medicine
- Development
- 2013
- 11
- PDF
References
SHOWING 1-10 OF 16 REFERENCES
NMR structure of the WIF domain of the human Wnt-inhibitory factor-1.
- Chemistry, Medicine
- Journal of molecular biology
- 2006
- 39
- PDF
Secreted antagonists of the Wnt signalling pathway
- Biology, Medicine
- Journal of Cell Science
- 2003
- 1,461
- PDF
Secreted Frizzled-related proteins: searching for relationships and patterns.
- Biology, Medicine
- BioEssays : news and reviews in molecular, cellular and developmental biology
- 2002
- 386
Wnt proteins are lipid-modified and can act as stem cell growth factors
- Biology, Medicine
- Nature
- 2003
- 2,138
- PDF
A new secreted protein that binds to Wnt proteins and inhibits their activites
- Biology, Medicine
- Nature
- 1999
- 679
A soluble form of Wnt-1 protein with mitogenic activity on mammary epithelial cells.
- Biology, Medicine
- Molecular and cellular biology
- 1995
- 80
- PDF
Wnt inhibitory factor-1 gene transfer inhibits melanoma cell growth.
- Biology, Medicine
- Human gene therapy
- 2007
- 49
The Wnt signaling pathway in development and disease.
- Biology, Medicine
- Annual review of cell and developmental biology
- 2004
- 4,716
- PDF
The extracellular matrix component WIF-1 is expressed during, and can modulate, retinal development
- Biology, Medicine
- Molecular and Cellular Neuroscience
- 2004
- 57
WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors
- Biology, Medicine
- Genes, chromosomes & cancer
- 2007
- 46