• DOI:10.1007/s11745-007-3144-3
Corpus ID: 31357937

Docking of Fatty Acids into the WIF Domain of the Human Wnt Inhibitory Factor-1

@article{Malinauskas2007DockingOF,
  title={Docking of Fatty Acids into the WIF Domain of the Human Wnt Inhibitory Factor-1},
  author={Tomas Malinauskas},
  journal={Lipids},
  year={2007},
  volume={43},
  pages={227-230}
}

Tomas Malinauskas

Published 2007

Biology, Medicine

Lipids

Palmitoylated Wnt proteins comprise a conserved family of secreted signaling molecules associated with variety of human cancers. WIF domain of the human WIF (Wnt inhibitory factor)-1 is sufficient for Wnt binding and signaling inhibition. Detailed interactions between Wnt and WIF-1 are not known. Computational docking was employed to identify a possible fatty acid binding site in the WIF domain. A putative binding site was identified inside the domain. WIF domain exhibited the highest affinity… CONTINUE READING

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