Docking-dependent regulation of the Rb tumor suppressor protein by Cdk4.

  title={Docking-dependent regulation of the Rb tumor suppressor protein by Cdk4.},
  author={Maura Wallace and Kathryn L. Ball},
  journal={Molecular and cellular biology},
  volume={24 12},
Phosphorylation of target proteins by cyclin D1-Cdk4 requires both substrate docking and kinase activity. In addition to the ability of cyclin D1-Cdk4 to catalyze the phosphorylation of consensus sites within the primary amino acid sequence of a substrate, maximum catalytic activity requires the enzyme complex to anchor at a site remote from the phospho-acceptor site. A novel Cdk4 docking motif has been defined within a stretch of 19 amino acids from the C-terminal domain of the Rb protein that… CONTINUE READING

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