Docetaxel serum protein binding with high affinity to alpha1-acid glycoprotein

  title={Docetaxel serum protein binding with high affinity to alpha1-acid glycoprotein},
  author={S. Urien and J. Barr{\'e} and C. Morin and A. Paccaly and G. Montay and J. Tillement},
  journal={Investigational New Drugs},
  • S. Urien, J. Barré, +3 authors J. Tillement
  • Published 2004
  • Chemistry, Medicine
  • Investigational New Drugs
  • SummaryThe binding of docetaxel to human plasma proteins was studied by ultrafiltration at 37°C and pH 7.4. Docetaxel was extensively (> 98%) plasma protein bound. At clinically relevant concentrations (1–5 μg/ml), the plasma binding was concentration-independent. Lipoproteins, alpha1-acid glycoprotein and albumin were the main carriers of docetaxel in plasma, and owing to the high interindividual variability of alpha1-acid glycoprotein plasma concentration, particularly in cancer, it was… CONTINUE READING
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