Docetaxel serum protein binding with high affinity to alpha1-acid glycoprotein

@article{Urien2004DocetaxelSP,
  title={Docetaxel serum protein binding with high affinity to alpha1-acid glycoprotein},
  author={Sa{\"i}k Urien and J{\'e}r{\^o}m{\'e} Barr{\'e} and Christophe Morin and Anne J Paccaly and Guy Montay and Jean Paul Tillement},
  journal={Investigational New Drugs},
  year={2004},
  volume={14},
  pages={147-151}
}
SummaryThe binding of docetaxel to human plasma proteins was studied by ultrafiltration at 37°C and pH 7.4. Docetaxel was extensively (> 98%) plasma protein bound. At clinically relevant concentrations (1–5 μg/ml), the plasma binding was concentration-independent. Lipoproteins, alpha1-acid glycoprotein and albumin were the main carriers of docetaxel in plasma, and owing to the high interindividual variability of alpha1-acid glycoprotein plasma concentration, particularly in cancer, it was… 
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References

SHOWING 1-10 OF 19 REFERENCES
Binding of taxol to human plasma, albumin and alpha 1-acid glycoprotein.
TLDR
The protein binding ofTaxol was found to dramatically decrease the red blood cell uptake of taxol, indicating nonspecific hydrophobic binding.
Role of alpha‐1 acid glycoprotein, albumin, and nonesterified fatty acids in serum binding of apazone and warfarin
TLDR
It is strongly suggested that when hypoalbuminemia is present and a drug binds to AAG with an affinity constant comparable to or higher than that to albumin, then fu will become dependent on the concentration of AAG.
Binding of indapamide to serum proteins and erythrocytes.
Effects of cancer and its treatments on plasma concentration of alpha1‐acid glycoprotein and propranolol binding
TLDR
The data imply that untreated or unsuccessfully treated cancer patients will have reduced free fractions for any drug for which AAG is an important binding protein, and successfully treated patients may have longitudinal changes towards normal.
Methadone plasma protein binding: Alterations in cancer and displacement from α1‐acid glycoprotein
  • F. Abramson
  • Biology
    Clinical pharmacology and therapeutics
  • 1982
TLDR
The concentrations required for significant displacement (27 μM), as well as the relatively low Ka for methadone, suggest that the free fraction of methadon will not be significantly affected by elevated methamphetamine concentrations or through displacement by other drugs that also bind to AAG.
The plasma protein binding of basic drugs.
  • P. Routledge
  • Medicine, Biology
    British journal of clinical pharmacology
  • 1986
The plasma protein binding of basic drugs appears to vary more than was at first assumed and is related to the marked intra-and interindividual differences in one of the chief binding proteins, AAG.
Determinants of plasma alpha 1-acid glycoprotein (AAG) concentrations in health.
TLDR
It is concluded that in addition to the known effects of age and gender, environmental (rather than genetic) factors largely determine the variance of AAG concentrations.
Pharmacokinetics and metabolism of Taxotere (docetaxel).
TLDR
The pharmacokinetics and metabolism of Taxotere have been studied after intravenous infusion in mice, dogs and cancer patients and large scale prospective population pharmacokinetic/pharmacodynamic studies have been implemented in ongoing phase II studies.
The taxoids: paclitaxel (Taxol) and docetaxel (Taxotere).
The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.
TLDR
The relatively low density of the lipoproteins was utilized by Lindgren, Elliott, and Gofman to separate them from the other serum proteins by ultracentrifugal flotation, and quantitation was subsequently performed by refractometric methods in the analytical ultracentRifuge.
...
1
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