Docetaxel loaded oleic acid-coated hydroxyapatite nanoparticles enhance the docetaxel-induced apoptosis through activation of caspase-2 in androgen independent prostate cancer cells.

@article{Luo2010DocetaxelLO,
  title={Docetaxel loaded oleic acid-coated hydroxyapatite nanoparticles enhance the docetaxel-induced apoptosis through activation of caspase-2 in androgen independent prostate cancer cells.},
  author={Yun Luo and You Ling and Wusheng Guo and Jun Pang and Weipeng Liu and Youqiang Fang and Xinqiao Wen and Kun Wei and Xin Gao},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2010},
  volume={147 2},
  pages={278-88}
}
Docetaxel (Dtxl) remains the preferred choice of improving the survival of patients with hormone refractory prostate cancer (HRPC), but many patients suffer from modest drug response and significant toxicity. In the present study, we investigated the efficiency of novel Dtxl loaded-[1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-carboxy(polyethylene glycol)]2000 (DSPE-PEG-COOH) stabilized-oleic acid (OA) coated hydroxyapatite (HA) nanoparticles (Dtxl-NPs) and gained insights into the… CONTINUE READING