Docetaxel-induced apoptosis in melanoma cells is dependent on activation of caspase-2.

@article{Mhaidat2007DocetaxelinducedAI,
  title={Docetaxel-induced apoptosis in melanoma cells is dependent on activation of caspase-2.},
  author={Nizar Mahmoud Mhaidat and Yufang Wang and Kelly Anne Kiejda and Xu Dong Zhang and Peter Hersey},
  journal={Molecular cancer therapeutics},
  year={2007},
  volume={6 2},
  pages={752-61}
}
Taxanes have a broad spectrum of activity against various human cancers, including melanoma. In this study, we have examined the molecular mechanism of docetaxel-induced apoptosis of human melanoma. We report that docetaxel induced varying degrees of apoptosis in a panel of melanoma cell lines but not in normal fibroblasts. Induction of apoptosis was caspase dependent and associated with changes in mitochondrial membrane potential that could be inhibited by overexpression of Bcl-2. Docetaxel… CONTINUE READING