Docetaxel-Resistance in Prostate Cancer: Evaluating Associated Phenotypic Changes and Potential for Resistance Transfer via Exosomes

@inproceedings{Corcoran2012DocetaxelResistanceIP,
  title={Docetaxel-Resistance in Prostate Cancer: Evaluating Associated Phenotypic Changes and Potential for Resistance Transfer via Exosomes},
  author={Claire Corcoran and Sweta Rani and Keith Philip O’Brien and Amanda J. O’Neill and Maria Prencipe and Rizwan Sheikh and Glenn F. Webb and Ray McDermott and William M. Watson and John S. Crown and Lorraine O’Driscoll},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Hormone-refractory prostate cancer remains hindered by inevitable progression of resistance to first-line treatment with docetaxel. Recent studies suggest that phenotypic changes associated with cancer may be transferred from cell-to-cell via microvesicles/exosomes. Here we aimed to investigate phenotypic changes associated with docetaxel-resistance in order to help determine the complexity of this problem and to assess the relevance of secreted exosomes in prostate cancer… CONTINUE READING
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