Doc2alpha is an activity-dependent modulator of excitatory synaptic transmission.

@article{Sakaguchi1999Doc2alphaIA,
  title={Doc2alpha is an activity-dependent modulator of excitatory synaptic transmission.},
  author={Gaku Sakaguchi and Toshiya Manabe and Kazuo Kobayashi and Sumihisa Orita and Tetsuhiko Sasaki and Akira Naito and Minoru Maeda and Hisako Igarashi and Goro Katsuura and Hajime Nishioka and Akira Mizoguchi and Shigeyoshi Itohara and Tomoyuki Takahashi and Yoshimi Takai},
  journal={The European journal of neuroscience},
  year={1999},
  volume={11 12},
  pages={
          4262-8
        }
}
Doc2alpha is a synaptic vesicle-associated Ca2 + -binding protein. To study the role of Doc2alpha in synaptic transmission and modulation, we generated homozygous null Doc2alpha mutant mice. In the CA1 region of hippocampal slices in the mutant mice, excitatory synaptic responses evoked with prolonged 5 Hz stimulation showed a significantly larger frequency facilitation followed by a steeper depression than those in wild-type mice, whereas there was no difference in synaptic transmission at… CONTINUE READING
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