• Chemistry, Medicine
  • Published in
    Canadian journal of…
  • DOI:10.1139/y04-048

Dobutamine alters carnitine metabolism in the neonatal piglet heart.

  title={Dobutamine alters carnitine metabolism in the neonatal piglet heart.},
  author={Rodrigo Azuero and Chittaranjan Debata and Marie Quinn and Kathleen Mcdonough and Jessica Thomson and Duna Penn},
  journal={Canadian journal of physiology and pharmacology},
  volume={82 7},
UNLABELLED The use of inotropic agents to support the neonatal heart after sepsis or hypoxia increases cardiac energy demand. Carnitine plays a vital role in energy, fuel metabolism. To test the hypothesis that inotropic agents affect carnitine metabolism, hearts from sow-fed piglets were isolated and perfused with an oxygenated buffer containing glucose and palmitate. Increasing dosages of dobutamine (DOB 2.5-15 microg/Kg body wt per min, 0.007-0.044 micromol/kg per min) or saline vehicle (SAL… CONTINUE READING