Doa1 targets ubiquitinated substrates for mitochondria-associated degradation

Abstract

Mitochondria-associated degradation (MAD) mediated by the Cdc48 complex and proteasome degrades ubiquitinated mitochondrial outer-membrane proteins. MAD is critical for mitochondrial proteostasis, but it remains poorly characterized. We identified several mitochondrial Cdc48 substrates and developed a genetic screen assay to uncover regulators of the Cdc48… (More)
DOI: 10.1083/jcb.201510098

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@inproceedings{Wu2016Doa1TU, title={Doa1 targets ubiquitinated substrates for mitochondria-associated degradation}, author={Xi Wu and Lanlan Li and Hui Jiang}, booktitle={The Journal of cell biology}, year={2016} }