Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial.

@article{Altman2002DoWW,
  title={Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial.},
  author={Douglas G. Altman and Guillermo Carroli and Lelia Duley and Barbara Farrell and Jack Moodley and James P. Neilson and David Smith},
  journal={Lancet},
  year={2002},
  volume={359 9321},
  pages={1877-90}
}
BACKGROUND Anticonvulsants are used for pre-eclampsia in the belief they prevent eclamptic convulsions, and so improve outcome. Evidence supported magnesium sulphate as the drug to evaluate. METHODS Eligible women (n=10141) had not given birth or were 24 h or less postpartum; blood pressure of 140/90 mm Hg or more, and proteinuria of 1+ (30 mg/dL) or more; and there was clinical uncertainty about magnesium sulphate. Women were randomised in 33 countries to either magnesium sulphate (n=5071… CONTINUE READING
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