Do the potential benefits outweigh the risks? An update on the use of ziconotide in clinical practice

@article{Bckryd2018DoTP,
  title={Do the potential benefits outweigh the risks? An update on the use of ziconotide in clinical practice},
  author={Emmanuel B{\"a}ckryd},
  journal={European Journal of Pain},
  year={2018},
  volume={22}
}
  • E. Bäckryd
  • Published 1 August 2018
  • Medicine
  • European Journal of Pain
Ziconotide is a selective and potent blocker of N‐type voltage‐gated calcium channels. It was approved by the Food and Drug Administration in 2004 and by the European Medicines Agency in 2005 for the treatment of severe chronic pain in patients needing intrathecal analgesia (ITA). The aim of this paper is to provide a practitioner‐oriented, educational, narrative, up‐to‐date review on the use of ziconotide in clinical pain medicine. Of special concern regarding safety is the partial incongruity… 
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14 Citations
Background Citations
2
Methods Citations
1

14 Citations

Intrathecal pain management with ziconotide: Time for consensus?
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Recommendations made by six pain specialists who discussed the rationale for ziconotide intrathecal analgesia (ITA) and the requirement for evidence‐based guidance on its use, from a European perspective are summarized.
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Though there is limited medical literature as to efficacy of any one drug, individualized multimodal therapy can provide significant analgesia to patients with chronic neuropathic pain.
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  • D. Dupoiron
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All recent recommendations highlight the efficiency of IDDS and propose to use it sooner, and technical innovations include new catheters and anchorage devices for easier placement and a lower rate of complication.
Systemic, Intrathecal, and Intracerebroventricular Antihyperalgesic Effects of the Calcium Channel Blocker CTK 01512-2 Toxin in Persistent Pain Models.
TLDR
Results reinforce the therapeutic potential of CTK 01512-2 to treat persistent pain conditions and offer a perspective to use the systemic route and increase the glial cell viability in the MTT reduction assay, and it may indicate a new approach to managing chronic pain.
Managing Chronic Non-Malignant Pain in the Elderly: Intrathecal Therapy
TLDR
Current knowledge regarding intrathecal opioid therapy is reviewed, focusing particularly on the use of IDD in elderly patients, and the arguments in favor of and against this therapy in elderly Patients are discussed.
Protective effect of a spider recombinant toxin in a murine model of Huntington's disease
Virtual insights on G protein inhibition and ion channel block – a computer-based study
TLDR
The present work focuses on understanding the mechanisms of action of two pharmaceutically relevant inhibitor protein systems and their target protein, the alpha- (α) subunit of a heterotrimeric G protein as well as conotoxins, venoms obtainable from marine cone snails, which can act as blockers of voltage-gated ion channels.
Pharmakologie der Nichtopioidanalgetika
TLDR
The basic pharmacology and main adverse effects of high-dose acetylsalicylic acid, traditional nonsteroidal anti-inflammatory drugs, and coxibs exhibit antipyretic and anti- inflammatory properties.
Ziconotide for spinal cord injury‐related pain
TLDR
This cohort study assessed responder rate and long‐term efficacy of intrathecal ziconotide in patients with pain related to spinal cord injury.
Neurobiological activity of conotoxins via sodium channel modulation.
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