Do tetracyclines and erythromycin exert anti‐acne effects by inhibition of P450‐mediated degradation of retinoic acid?

@article{HellmannRegen2014DoTA,
  title={Do tetracyclines and erythromycin exert anti‐acne effects by inhibition of P450‐mediated degradation of retinoic acid?},
  author={J. Hellmann-Regen and I. Herzog and Norina Fischer and I. Heuser and F. Regen},
  journal={Experimental Dermatology},
  year={2014},
  volume={23}
}
  • J. Hellmann-Regen, I. Herzog, +2 authors F. Regen
  • Published 2014
  • Biology, Medicine
  • Experimental Dermatology
  • For decades, retinoic acid (RA) is known as the most potent therapeutic option in the therapy of acne and altered homeostasis of endogenous retinoids has been discussed in the context of acne pathogenesis. Besides retinoids, antibiotics such as tetracyclines or erythromycin are well established in acne pharmacotherapy. Accumulating evidence points towards common molecular pathways being targeted by both RA and anti‐acne antibiotics; however, a precise ‘common denominator’ connecting these… CONTINUE READING
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