Do serum angiopoietin-1, angiopoietin-2, and their receptor Tie-2 and 4G/5G variant of PAI-1 gene have a role in the pathogenesis of preeclampsia?

@article{Kamal2011DoSA,
  title={Do serum angiopoietin-1, angiopoietin-2, and their receptor Tie-2 and 4G/5G variant of PAI-1 gene have a role in the pathogenesis of preeclampsia?},
  author={Manal Mohammed Kamal and Waleed El-Khayat},
  journal={Journal of investigative medicine : the official publication of the American Federation for Clinical Research},
  year={2011},
  volume={59 7},
  pages={1147-50}
}
OBJECTIVE To evaluate whether serum angiogenesis markers such as angiopoietins (Ang-1, Ang-2) and their receptor (Tie-2) are altered in women with preeclampsia. We also performed genotyping to determine if the 4G/5G genotypes of -675 PAI-1 gene may play a role in the pathogenesis of preeclampsia. MATERIALS AND METHODS Sixty-eight pregnant women with preeclampsia were compared to 35 normotensive pregnant women and 24 normotensive nonpregnant women in a cross-sectional study. Using enzyme… CONTINUE READING

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