Do schizotypal symptoms mediate the relationship between genetic risk for schizophrenia and impaired neuropsychological performance in co-twins of schizophrenic patients?

@article{Johnson2003DoSS,
  title={Do schizotypal symptoms mediate the relationship between genetic risk for schizophrenia and impaired neuropsychological performance in co-twins of schizophrenic patients?},
  author={Jennifer K Johnson and Annamari Tuulio-Henriksson and Tiia Pirkola and Matti O. Huttunen and Jouko L{\"o}nnqvist and Jaakko Kaprio and Tyrone D. Cannon},
  journal={Biological psychiatry},
  year={2003},
  volume={54 11},
  pages={1200-4}
}
BACKGROUND Neurocognitive deficits and symptoms of schizotypal personality disorder are both elevated in the first-degree relatives of schizophrenic patients, but their relationship to each other and their potential common genetic source remain unclear. METHODS Fifty unaffected co-twins of schizophrenic patients and 123 control twins were assessed with a neuropsychological battery and structured clinical interviews. RESULTS Working memory was influenced by genetic risk for schizophrenia but… CONTINUE READING

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