Do rats have a prefrontal cortex?

  title={Do rats have a prefrontal cortex?},
  author={Harry B. M. Uylings and Henk J. Groenewegen and Bryan E Kolb},
  journal={Behavioural Brain Research},

Cellular Mechanisms of Working Memory and its Modulation by Dopamine in the Prefrontal Cortex of Primates and Rats

Seminal findings from brain lesion and behavioral electrophysiology studies determined that different subregions of the PFC engage in distinct cognitive functions, and the observation that cells in the dorsolateral PFC regions exhibit persistent activity in response to external stimuli, after the stimuli have ceased is observed.

Do All Mammals Have a Prefrontal Cortex

Organization and Plasticity of the Prefrontal Cortex of the Rat

It is argued here that the rat is an excellent model for studying frontal functions and plasticity in humans and other primates.

5. A comparative perspective on executive and motivational control by the medial prefrontal cortex

This chapter tries to answer what, if anything, is rodent prefrontal cortex based on studies of the anatomical connectivity between the medial prefrontal cortex (mPFC) and the hypothalamus, and on recent studies on mPFC during performance of simple reaction-time tasks that suggest that medial prefrontal regions have a privileged role in controlling the autonomic nervous system.

Finding prefrontal cortex in the rat

Comparing the prefrontal cortex of rats and primates: Insights from electrophysiology

Anatomical evidence supports the view that the rat medial PFC is related to both the primate anterior cingulate cortex (ACC) and the dorsolateral PFC, and seems to combine elements of thePrimate ACC and dorsol lateral PFC at a rudimentary level.

What, If Anything, Is Rodent Prefrontal Cortex?

A survey of established PFC researchers on their use of anatomical terms and a proposed alternative scheme for interpreting data from rodent studies, based on structural analysis of the corpus callosum and nomenclature used in research on the anterior cingulate cortex of primates.

What constitutes the prefrontal cortex?

During evolution, the prefrontal region grew in size relative to the rest of the cortex. It reached its largest extent in the human brain, where it constitutes 30% of the total cortical area. This

Medial Prefrontal Cortex Supports Recollection, But Not Familiarity, in the Rat

Signal detection analyses indicated that rats with mPFC damage had a curvilinear and symmetrical receiver operating characteristic (ROC) curve, indicating that mP FC damage severely reduced recollection-based performance, while sparing familiarity, and is complementary to the selective deficit in hit rate observed after hippocampal damage.



Do Rats Have Prefrontal Cortex? The Rose-Woolsey-Akert Program Reconsidered

  • T. Preuss
  • Biology, Psychology
    Journal of Cognitive Neuroscience
  • 1995
Assessment of rat frontal cortex suggests that rats probably do not provide useful models of human dorsolateral frontal lobe function and dysfunction, although they might prove valuable for understanding other regions of frontal cortex.

The anatomical relationships of the prefrontal cortex with limbic structures and the basal ganglia

The results of tracing studies in rats indicate that these thalamic and limbic inputs both at the level of the PFC and the ventral striatum show various patterns of convergence and segregation, which leads to the conclusion that the P FC-ventral striatal system consists of a number of smaller modules.

Functions of the frontal cortex of the rat: A comparative review

  • B. Kolb
  • Biology, Psychology
    Brain Research Reviews
  • 1984

Rodent models of prefrontal cortical function

Diverse thalamic projections to the prefrontal cortex in the rhesus monkey

The goal was to determine the proportion of labeled neurons contributing to this projection system by the mediodorsal (MD) nucleus compared to those distributed in other thalamic nuclei, and to investigate the relationship ofThalamic projections to specific architectonic areas of the prefrontal cortex.

Postnatal development of amygdaloid projections to the prefrontal cortex in the rat studied with retrograde and anterograde tracers

The observations suggest that the development of amygdala innervation of the PFC parallels the emergence of PFC cytoarchitectural organization, and may play a role in the developmental plasticity reported for several of these functions.