Do protons block Na+ channels by binding to a site outside the pore?

Abstract

In a detailed structural model of the Na+ channel which has evolved over the past decade, the selectivity of the channel for cations1,2, the voltage-dependence of channel block by protons3 and other small cations2, and block by tetrodotoxin (TTX)4,5 all depend on the presence of a negatively charged site inside the channel that is part of a constriction… (More)
DOI: 10.1038/298165a0

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