Do preoperative factors predict subsequent diagnosis of Crohn’s disease after ileal pouch‐anal anastomosis for ulcerative or indeterminate colitis?

  title={Do preoperative factors predict subsequent diagnosis of Crohn’s disease after ileal pouch‐anal anastomosis for ulcerative or indeterminate colitis?},
  author={Genevieve B. Melton and Ravi P. Kiran and Victor W. Fazio and J He and Bo Shen and John R. Goldblum and Jean-Paul Achkar and Ian C. Lavery and Feza H. Remzi},
  journal={Colorectal Disease},
Aim  The aim of this study was to determine preoperative clinical factors associated with subsequent diagnosis revision to Crohn’s disease (CD) following total proctocolectomy with ileal pouch‐anal anastomosis (IPAA) for ulcerative colitis (UC) or indeterminate colitis (IC) patients. 

Patchy colitis, and young age at diagnosis and at the time of surgery predict subsequent development of Crohn's disease after ileal pouch‐anal anastomosis surgery for ulcerative colitis

The aim of this study was to identify preoperative and perioperative predictors for the subsequent development of CD in patients who had IPAA for presumed UC.

Antitumour necrosis factor therapy is associated with de novo Crohn’s disease after ileal pouch‐anal anastomosis

  • A. TruongK. Zaghiyan P. Fleshner
  • Medicine
    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • 2021
This prospective study is the first to suggest an association between preoperative TNFi exposure and the development of denovoCD, and survival analysis of TNFi era patients revealed a significant increase in denovo CD risk in those with preoperativeTNFi exposure.

Update on the Surgical Treatment of Inflammatory Bowel Disease

This chapter will explore the current state of surgical therapy for inflammatory bowel disease, including management of Crohn’s fibrostenotic disease, perianal disease, application of the minimally invasive approach, and approach to determining the choice of surgery in patients with ulcerative colitis.

Diagnosis and Differential Diagnosis of Crohn’s Disease of the Ileal Pouch

D diagnosis, differential diagnosis, and management of Crohn’s disease of the ileal pouch have been challenging and a multidisciplinary approach with gastroenterologists, colorectal surgeons, gastrointestinal pathologists, and radiologists is advocated.

When “pouchitis” isn׳t pouchitis: Crohn׳s disease and surgical complications

D diagnosis and management of Crohn׳s disease and surgical complications affecting the ileal pouch are reviewed.

Common Inflammatory Disorders and Neoplasia of the Ileal Pouch: A Review of Histopathology

Ileal pouch-anal anastomosis (IPAA) is the standard restorative procedure after proctocolectomy in patients with ulcerative colitis (UC) who require colectomy. The ileal pouch is susceptible to a

Risk Factors for Chronic Inflammatory Disorders of Ileal Pouch

Redo Ileal Pouch Anal Anastomosis After a Failed Pouch In Patients With Crohn's Disease: Is It Worth Trying?

Redo pouch can be offered to selected patients with colonic Crohn's disease diagnosed at the time of their primary pouch, as compared to a retrospective analysis of a prospectively maintained pouch database (1983-2017).

Diagnosis of Pouch Disorders: Histology

Crohn's Disease after Proctocolectomy and Ileal Pouch Anal Anastomosis for Ulcerative Colitis.

D diagnosis of Crohn's disease can occur at a distance from surgery with an increasing cumulative incidence over time and preoperative predictive factors are few and should not determine candidacy for surgery.



Pathological subgroups may predict complications but not late failure after ileal pouch‐anal anastomosis for indeterminate colitis

This study evaluated pathological subgroups of IndC to identify a predictor of increased complication rates after IPAA for IndC.

Results at up to 20 years after ileal pouch–anal anastomosis for chronic ulcerative colitis

Ileal pouch–anal anastomosis (IPAA) is performed routinely for chronic ulcerative colitis and may be useful for diagnosis of other types of colitis.

Crohn's disease of the ileal pouch: Reality, diagnosis, and management

  • B. Shen
  • Medicine
    Inflammatory bowel diseases
  • 2009
It is advisable to inform ulcerative colitis patients before the surgery of the potential risk for Crohn's disease along with other inflammatory and noninflammatory complications.

Family History and Serology Predict Crohn’s Disease after Ileal Pouch-Anal Anastomosis for Ulcerative Colitis

Patients with ulcerative colitis and indeterminate colitis with a family history of Crohn’s disease or preoperative anti-Saccharomyces cerevisiae immunoglobulin-A seropositivity are more likely to be diagnosed with Crohn's disease after ileal pouch-anal anastomosis.

The Fate of the Ileal Pouch in Patients Developing Crohn’s Disease

Preoperative characteristics, including the presence of anal disease, were not predictive of subsequent pouch failure, and the routine application of ileal pouch-anal anastomosis is chosen not to recommend in any subset of patients with known Crohn’s disease.

Long-Term Results of Ileal Pouch–Anal Anastomosis in Crohn's Disease

A retrospective analysis of the long-term development of patients with an ileal pouch–anal anastomosis (IPAA) in whom the definitive anatomopathological diagnosis was CD to compare their development with that of patients in which the diagnosis of ulcerative colitis was confirmed.

Analysis of the Outcome of Ileal Pouch-Anal Anastomosis in Patients With Crohn’s Disease

The secondary diagnosis of Crohn’s disease after ileal pouch-anal anastomosis is associated with protracted freedom from clinically evident Crohn's disease, low pouch loss rate, and good functional outcome.

A proposed classification of ileal pouch disorders and associated complications after restorative proctocolectomy.

Serologic Responses in Indeterminate Colitis Patients Before Ileal Pouch-Anal Anastomosis May Determine Those at Risk for Continuous Pouch Inflammation

Indeterminate colitis patients who have a positive antibody reactivity profile before ileal pouch-anal anastomosis have a significantly higher incidence of continuous pouch inflammation after surgery than those with a negative profile.

Risk Factors for Clinical Phenotypes of Crohn's Disease of the Ileal Pouch

Each of the three phenotypes of CD of the pouch was associated with certain risk factors, suggesting that each of these diseases has a different etiology and disease process.