Do porins inhibit the macrophage phagocyting activity by stimulating the adenylate cyclase?

Abstract

Porins interact with macrophage membranes and inhibit their phagocyting activity. We have tested the porin effect on a biologically relevant membrane-bound enzymic activity, the adenylate cyclase system, which appears to be stimulated both in the presence of Mn2+ and Mg2+ or Mg2+ + Gpp(NH)p. Moreover, for mice macrophages incubated in the presence of porins… (More)

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@article{Donato1986DoPI, title={Do porins inhibit the macrophage phagocyting activity by stimulating the adenylate cyclase?}, author={Angela Di Donato and Giulio Francesco Draetta and Giuseppina Illiano and Michele Tufano and Linda Sommese and Francesca Galdiero}, journal={Journal of cyclic nucleotide and protein phosphorylation research}, year={1986}, volume={11 2}, pages={87-97} }