Do oxysterols control cholesterol homeostasis?

  title={Do oxysterols control cholesterol homeostasis?},
  author={Ingemar Bj{\"o}rkhem},
  journal={The Journal of clinical investigation},
  volume={110 6},
are oxygenated derivatives of cholesterol with a very short half-life relative to cholesterol. As a consequence they are present in very low concentrations in all mammalian systems, almost invariably accompanied by 10 3-to 10 6-fold excess of cholesterol. Oxysterols are important intermediates in a number of hepatic and extrahepatic catabolic pathways, most of which generate water-soluble bile acids as final products. Based on largely indirect evidence, and in spite of their low levels in vivo… CONTINUE READING