Do metastases arise from pre-existing subpopulations of cancer cells?

@article{Weiss1983DoMA,
  title={Do metastases arise from pre-existing subpopulations of cancer cells?},
  author={Leonard Weiss and John C. Holmes and Pamela M. Ward},
  journal={British Journal of Cancer},
  year={1983},
  volume={47},
  pages={81 - 89}
}
The hypothesis that metastases arise from pre-existing metastatic sub-populations of cancer cells with heritable metastasis-related characteristics, was tested by comparing the metastatic behaviour of cancer cells derived from pulmonary metastases with those from corresponding primary tumours, after implanting them subcutaneously in mice. In the case of KHT osteosarcomas and B16 melanomas, injected minces of metastases gave rise to more pulmonary metastases than cells derived from minces of the… CONTINUE READING