Do matrix metalloproteinases MMP-2 and MMP-9 (gelatinases) play a role in renal development, physiology and glomerular diseases?

@article{Lelongt2001DoMM,
  title={Do matrix metalloproteinases MMP-2 and MMP-9 (gelatinases) play a role in renal development, physiology and glomerular diseases?},
  author={Brigitte Lelongt and B Legallicier and R{\'e}mi Piedagnel and Pierre Ronco},
  journal={Current opinion in nephrology and hypertension},
  year={2001},
  volume={10 1},
  pages={7-12}
}
Metalloproteinases MMP-2 and MMP-9 (also called gelatinases) are involved in cell invasion and in embryonic development and organogenesis. A growing number of reports suggest that MMP-2 and MMP-9 play some role in renal development, renal tubule physiology and glomerular pathophysiology. This editorial will focus on recent controversial data, especially those obtained from studies on MMP-9-deficient mice, which shed new light on the functions of gelatinases in normal and diseased kidneys. 

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