Do low‐serum vitamin E levels increase the risk of Alzheimer disease in older people? Evidence from a meta‐analysis of case‐control studies

@article{Dong2018DoLV,
  title={Do low‐serum vitamin E levels increase the risk of Alzheimer disease in older people? Evidence from a meta‐analysis of case‐control studies},
  author={Yonghai Dong and Xiaodan Chen and Yun Liu and Yan Shu and Ting Chen and Lei Xu and Meng Li and Xihong Guan},
  journal={International Journal of Geriatric Psychiatry},
  year={2018},
  volume={33},
  pages={e257 - e263}
}
Whether low‐serum vitamin E increases the risk of Alzheimer disease (AD) in older people remains inconclusive. This meta‐analysis aims to synthesize evidence‐based case‐control studies to evaluate the association between serum vitamin E and the risk of AD. 
View on Wiley
ncbi.nlm.nih.gov
15 Citations
Background Citations
2
Results Citations
4

15 Citations

Citation Type

Citation Type

Vitamin E and Alzheimer’s disease: what do we know so far?
TLDR
Despite a strong rationale in support of a beneficial role for vitamin E for the treatment of AD, the evidence remains inconclusive and the clinical safety of vitamin E remains controversial and warrants further investigation.
A meta-analysis of peripheral tocopherol levels in age-related cognitive decline and Alzheimer’s disease
TLDR
It is suggested that lower α-tocopherol levels have a strong association with AD and MCI supporting evidence for the role of diet and vitamin E in AD risk and age-related cognitive decline.
The Effectiveness of Vitamin E Treatment in Alzheimer’s Disease
TLDR
The studies with and without positive results in Alzheimer’s disease are reviewed and the reasons why vitamin E as treatment sometimes has positive results on cognition but at others, it does not are discussed.
Vitamins in Alzheimer’s Disease—Review of the Latest Reports
TLDR
A properly balanced diet, as well as the use of appropriate supplementation, can contribute to improving the clinical condition of patients with AD.
Role of Vitamin E in the Treatment of Alzheimer’s Disease: Evidence from Animal Models
TLDR
Experimental models showed that vitamin E supplementation, by decreasing oxidative stress, may be a good strategy to improve cognitive and memory deficits, and the combination of vitamin E with other antioxidant or anti-inflammatory compounds may increase its efficacy.
Diet Associated with Inflammation and Alzheimer’s Disease
TLDR
A review of the potential conditions and factors that stimulate the inflammatory processes in AD and an understanding of inflammatory mechanisms influencing the development of AD may help to protect against dementia and AD.
Dietary intake of tocopherols and risk of incident disabling dementia
TLDR
Dietary tocopherol intake was inversely associated with risk of disabling dementia, but its independent effect was uncertain owing to a high intercorrelation of α-linolenic linoleic acids with total tocop herol intake.
Alzheimer’s Disease, Inflammation, and the Role of Antioxidants
TLDR
The consumption of antioxidants and nutrients, specifically vitamin E, caffeine, and turmeric, may slow the progression of AD and can be found in a wide variety of dietary foods.
Vitamin E for the management of major depressive disorder: possible role of the anti-inflammatory and antioxidant systems.
TLDR
It is suggested that vitamin E has potential to be used as an adjuvant for the management of MDD, but more studies are clearly needed to ascertain the efficacy of vitamin E for alleviating depressive symptoms.
Dietary Patterns and Cognitive Function among Older Community-Dwelling Adults
TLDR
Adherence to a healthy diet with foods high in PUFA and vitamin E and a low sugar to protein ratio, as typified by a Mediterranean diet, may be beneficial for cognitive health in late life.
...
1
2
...

References

SHOWING 1-10 OF 34 REFERENCES
Altered plasma antioxidant status in subjects with Alzheimer's disease and vascular dementia
TLDR
A cross‐sectional comparison of blood markers of oxidative stress in two groups of patients with Alzheimer's disease and vascular dementia and a control group is made.
Dietary intakes of vitamin E, vitamin C, and β-carotene and risk of Alzheimer's disease: a meta-analysis.
TLDR
Dietary intakes of the most common three antioxidants can lower the risk of AD, with vitamin E exhibiting the most pronounced protective effects.
Plasma Levels of Antioxidants Are Not Associated with Alzheimer’s Disease or Cognitive Decline
TLDR
The findings suggest no association between plasma levels of vitamin A and E and AD or CD in non-demented subjects.
Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of α‐/γ‐tocotrienols and γ‐tocopherol
TLDR
Evaluated the accuracy of combined structural magnetic resonance imaging measures and plasma levels of vitamin E forms, including all eight natural vitamin E congeners, in differentiating individuals with Alzheimer's disease and mild cognitive impairment (MCI) from cognitively intact control (CTL) subjects.
Effects of Vitamin E on Cognitive Performance during Ageing and in Alzheimer’s Disease
TLDR
The benefit of vitamin E as a treatment for neurodegenerative disorders is still under debate and this review focuses on those studies that mostly have contributed to clarifying the exclusive function of Vitamin E in relation to brain ageing and AD.
Functional Vitamin E Deficiency in ApoE4 Patients with Alzheimer’s Disease
TLDR
The results suggest that oxidative stress-induced injury and protection by VitE in AD are related to the ApoE phenotype, which strongly supports the hypothesis of an impairment of lipophilic antioxidant delivery to neuronal cells in AD leading to a tissular antioxidant deficiency which could facilitate oxidative stress.
Homocysteine, antioxidant vitamins and lipids as biomarkers of neurodegeneration in Alzheimer's disease versus non-Alzheimer's dementia.
TLDR
The results obtained suggest that elevated serum tHcy and decreased levels of vitamins A and E are associated with an increased risk of non-Alzheimer's dementias, although further studies involving a larger cohort are now needed to verify these results.
Plasma Antioxidant Status, Immunoglobulin G Oxidation and Lipid Peroxidation in Demented Patients: Relevance to Alzheimer Disease and Vascular Dementia
TLDR
Dementia is associated with the depletion of a large spectrum of antioxidant micronutrients and with increased protein oxidative modification, which might be relevant to the pathophysiology of dementing disorders, particularly in light of the recently suggested importance of the vascular component in AD development.
Vitamin E and enzymatic/oxidative stress-driven oxysterols in amnestic mild cognitive impairment subtypes and Alzheimer's disease.
TLDR
Results suggest that AD patients have upregulated cerebral oxidative stress or a nutritional deficit of vitamin E, and the oxysterols investigated here are not useful markers for diagnosing AD or MCI.
Increased lipoprotein oxidation in Alzheimer's disease.
TLDR
The findings suggest that lipoprotein oxidation may be important in the development of AD and the in vitro measurement of lipid peroxidation in CSF might become a useful additional marker for diagnosis of AD.
...
1
2
3
4
...