Do immune cells promote the pathology of dystrophin-deficient myopathies?

@article{Spencer2001DoIC,
  title={Do immune cells promote the pathology of dystrophin-deficient myopathies?},
  author={Melissa J Spencer and James G. Tidball},
  journal={Neuromuscular disorders : NMD},
  year={2001},
  volume={11 6-7},
  pages={556-64}
}
Many features of dystrophin-deficient muscle pathology are not clearly related to the loss of mechanical support of the muscle membrane by dystrophin. In the present review, evidence that supports a role for the immune system in promoting the pathology of dystrophinopathy is presented. The findings summarized here indicate that specific, cellular immune responses by cytotoxic T-lymphocytes and helper T-lymphocytes contribute to muscle pathology in dystrophin-deficient muscle, and that removal… CONTINUE READING