Do general anaesthetics act by competitive binding to specific receptors?

  title={Do general anaesthetics act by competitive binding to specific receptors?},
  author={Nicholas P Franks and William Robert Lieb},
Most proteins are insensitive to the presence of anaesthetics at concentrations which induce general anaesthesia, while some are inhibited by certain agents but not others1. Here we show that, over a 100,000-fold range of potencies, the activity of a pure soluble protein (firefly luciferase) can be inhibited by 50% at anaesthetic concentrations which are essentially identical to those which anaesthetize animals. This identity holds for inhalational agents (such as halothane, methoxyflurane and… CONTINUE READING
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