Do general anaesthetics act by competitive binding to specific receptors?

@article{Franks1984DoGA,
  title={Do general anaesthetics act by competitive binding to specific receptors?},
  author={Nicholas P Franks and William Robert Lieb},
  journal={Nature},
  year={1984},
  volume={310},
  pages={599-601}
}
Most proteins are insensitive to the presence of anaesthetics at concentrations which induce general anaesthesia, while some are inhibited by certain agents but not others1. Here we show that, over a 100,000-fold range of potencies, the activity of a pure soluble protein (firefly luciferase) can be inhibited by 50% at anaesthetic concentrations which are essentially identical to those which anaesthetize animals. This identity holds for inhalational agents (such as halothane, methoxyflurane and… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 126 extracted citations

Mechanism of anesthetic action: oxygen pathway perturbation hypothesis.

Medical hypotheses • 2001
View 4 Excerpts
Highly Influenced

Mapping the sevoflurane-binding sites of calmodulin

Pharmacology research & perspectives • 2014
View 2 Excerpts
Highly Influenced

In vivo measurement of protein functional changes

International journal of biological sciences • 2009
View 4 Excerpts
Highly Influenced

Volatile anesthetics bind rat synaptic snare proteins.

Anesthesiology • 2005
View 12 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…