Do free radicals play causal role in atherosclerosis? Low density lipoprotein oxidation and vitamin E revisited

@inproceedings{Niki2011DoFR,
  title={Do free radicals play causal role in atherosclerosis? Low density lipoprotein oxidation and vitamin E revisited},
  author={Etsuo Niki},
  booktitle={Journal of clinical biochemistry and nutrition},
  year={2011}
}
Lipid peroxidation induced by free radicals has been implicated in the pathogenesis of various diseases. Numerous in vitro and animal studies show that oxidative modification of low density lipoprotein (LDL) is an important initial event of atherosclerosis. Vitamin E and other antioxidants inhibit low density lipoprotein oxidation efficiently in vitro, however, human clinical trials with vitamin E have not yielded positive results. The mixed results for vitamin E effect may be ascribed… CONTINUE READING