Do endogenous opioids contribute to the bradycardia of rats with obstructive cholestasis?

@article{Gaskari2002DoEO,
  title={Do endogenous opioids contribute to the bradycardia of rats with obstructive cholestasis?},
  author={Seyed Ali Gaskari and Ali R Mani and Shahram Ejtemaei-Mehr and Khodadad Namiranian and Houman Homayoun and Hossein Ahmadi and Ahmad Reza Dehpour},
  journal={Fundamental & clinical pharmacology},
  year={2002},
  volume={16 4},
  pages={273-9}
}
Endogenous opioids have nitric oxide (NO)-dependent cardiovascular actions. In the light of biological evidence of accumulation of endogenous opioids in cholestasis and also existence of NO-dependent bradycardia in cholestatic subjects, this study was carried out to evaluate the role of endogenous opioids in the generation of bradycardia in a rat model of cholestasis. Male Sprague-Dawley rats were used to induce cholestasis by surgical ligation of the bile duct, with sham-operated animals… CONTINUE READING